Chelsea  suffered a frustrating loss at the weekend as well as face multiple suspensions to tack onto their domestic injury issues.
The home side have the advantage of an away goal from the opening 1-1 leg of the tie, but Didier Drogba 's return to Stamford Bridge for the first time in new colours will see him hoping to secure something special to prove to his former employers and fans he still has what it takes.
Additionally Wesley Sneijder is likely to have his tail up for the match against his old manager whom he helped to win the Italian treble for.
Both sides have several injury concerns, but both are expected to field their strongest sides regardless of the issues.
The Blues have something to prove as they look to head to the next round but have to put in a shift if they are going to silence the Turkish giants without a major fight.
It is certain to be a great battle between Drogba and John Terry and will be exciting to watch.
Chelsea XI: Cech: Ivanovic, Cahill, Terry, Azpilicueta; Lampard, Ramires; Willian, Oscar, Hazard; Eto'o.
Galatasaray XI: Muslera: Eboue, Balta, Chedjou, Telles; Kurtulus, Inan, Melo; Sneijder; Yilmaz, Drogba.