A victory at home would be enough to see the Italians through to the Knockout Stage as long as bottom of Group F side Marseille manage to earn at least a draw against Borussia Dortmund .
The German side are in the drivers seat as if they win it does not matter if Napoli win or not.
However, as no French club has even failed to secure points in the UEFA Champions League Group Stages, Marseille will be hoping to take advantage of an injury plagued Dortmund and give Napoli the opening they need to advance.
The continued absence of Marek Hamsik will be a burden for the club and Rafael Benitez will be looking for summer signing Dries Mertens to live up to his abilities and hype.
Arsenal on the other hand know they are in the drivers seat, but manager Arsene Wenger will be looking for points to ensure that his side have a more favorable draw in the coming round.
Manager Arsene Wenger will likely give a few key players a rest as a point would be all that is necessary to be the top of the group and with the North Londoners taking on Manchester City at the weekend and the Citizens now riding high after an impressive comeback victory over Bayern Munich in Germany on Tuesday evening.
Napoli XI: Reina; Maggio, Albiol, Britos, Armero; Behrami, Inler; Callejon, Pandev, Miertens; Higuain.
Arsenal XI: Szczesny; Jenkinson, Mertesacker, Koscielny, Gibbs; Ramsey, Arteta; Wilshere, Ozil, Cazorla; Giroud.