However, this weekend the Blues get to turn the tables as Stamford Bridge takes the place of the windy confines of the Britannia and will see Jose Mourinho's side confident of progressing to the next round.
Kevin De Bruyne, Juan Mata and Michael Essien all have moved on and Mourinho's side will likely see newly returned Nemanja Matic in the first team as well as a rare start for Demba Ba.
Liverpool loanee, Oussama Assaidi was the hero in the last meeting between the sides and is expected to make his way into the Potters first team as well as nearly arrived Manchester City youngster John Guidetti.
The Blues have lost one of their last 30 FA Cup ties and have kept five clean sheets in their last five meetings against the visitors at the Bridge.
Mourinho's side are heavily favored to make their way to the 5th round and should have no trouble against Stoke with the Potter's having lost six straight in West London.
Chelsea XI: Schwarzer; Ivanovic, Luiz, Terry, Cole; Ramires, Matic; Schurrle, Oscar, Hazard; Ba.
Potters XI: Butland; Cameron, Shawcross, WIlson, Pieters; N'Zonzi, Palacios; Walters, Ireland, Assaidi; Guidetti.