The Toffees are hosting the Reds in their 221st meeting of all time between all competitions in which the Reds hold the edge 88W-66D-66L over their close rivals.
Adding to the excitement of the always hotly contested match is that only three points separate the two clubs in the top six of the table in a match that could see the Toffees jump to the top three alongside of Liverpool if they manage a win at home.
Ross Barkley and Romelu Lukaku are the potential hero's for Everton as the two youngsters are ripe for a major role in what could be one of their biggest matches of the campaign.
Barkley could be dropped in favor of Leon Osman, but the faith that Roberto Martinez has shown his rising star could set him up to shine in what could be his coming of age match in blue.
Daniel Sturridge has been questionable all week, but is expected to slot in next to Luis Suarez at the top of the Reds attack as the two of the joint leading scorers in the Premier League will look to continue their dominate run against their rivals.
With no fresh injury news to Brendan Rodgers, the Reds manager is likely to go with the same 4-4-2 lineup that thrashed Fulham two weeks ago at Anfield.
The return of Philippe Coutinho and Glen Johnson continues to add even more attacking prowess to the Reds side and Rodgers could have his team hitting their stride just in time for the busiest part of the season. Iago Aspas, Jose Enrique and Sebastian Coates remain sidelined for the foreseeable future.
Likewise nothing new is reported from Everton on the injury side as Darron Gibson and Arouna Kone remain long-term absentees.