Manager Brendan Rodgers  is likely to be forced to insert potential exit bound defender Martin Skrtel as emergency cover for Kolo Toure if he is unable to play Sunday.
The Ivorian suffered an undisclosed groin injury against Notts County and all that is known from Rodgers' press conference Friday is that, "It is not as bad," as the club believed it to be.
Iago Aspas could be a surprise major key to the match as the Reds will look for that little something extra to keep getting at United in order to break through their defense.
Manchester United  will once again look to Wayne Rooney to pull the strings in attack as he was excellent with that against Chelsea.
The Red Devils are likely to keep the same lineup they did against the Blues and will put up a great challenge.
The experience of a player like Skrtel coming into the side for Liverpool will see forward Robin Van Persie have a tougher time than he might have had against a lessor experienced player such as Andre Wisdom if he were in the first team.
It is certain to be an interesting return to Anfield for former Everton Boss David Moyes, and the magnitude of a match in England gets no larger than when the Reds of Liverpool take on the Reds of Manchester in the famous Northwest Derby.
Liverpool: Mignolet, Johnson, Skertel, Agger, Enrique, Gerrard, Lucas, Henderson, Aspas, Coutinho, Sturridge.
Manchester United: De Gea, Jones, Ferdinand, Vidic, Evra, Cleverly, Carrick, Valencia, Rooney, Welbeck, Van Persie.