With both sides heavily favored to reach the knockout stages, this will be a massive test for either nation and both will be looking to come out on top.
Having lost several players in the build up to the World Cup Germany now only have Bastian Schweinsteiger as a doubt for the match while Cristiano Ronaldo has been cleared for Portugal leaving them fully fit for the tie.
Without Marco Reus, Germany are expected to field Mario Gotze at the head of the attack, but could call on veteran Miroslav Klose as he is typically a man for big occasions on the national stage even in his mid-thirties.
Germany will have to be compact at the back to help avoid any early hiccups in their strategy as Portugal know that despite the German's massive goal haul over qualifying they at times were porous at the back and Ronaldo will look to exploit that.
Portugal have gained much confidence in their last few months and despite having lost the Germany in their last three meetings, the Portuguese are expected to have a strong chance at a draw.
Both Pepe and Bruno Alves are fully fit and will be a physical back line for Gotze or Klose to contend with.
You can never underestimate the Portuguese midfield of Raul Meireles and Joao Moutinho just as the left side of Germany's attack in Lukas Podolski have both cropped up with some key performances in the past and it is certain to make for an exciting match.
Germany Starting XI: Neuer: Howedes, Mertesacker, Hummels, Durm; Khedira, Lahm; Muller, Ozil, Podolski; Klose.
Portugal Starting XI: Patricio: Pereira, Alves, Pepe, Coentrao; Meireles, Carvalho, Moutinho; Varela, Almeida, Ronaldo.