Manchester United (3-3-2) continue to struggle to find their feet, but their potent attack has been mostly enough to overcome their continued defensive frustrations. However, against Chelsea they are likely to be pushed to their limits and hopefully for their fans and Louis Van Gaal those do not break.
Wayne Rooney remains suspended while Angel Di Maria, Ander Herrera, Antonio Valencia, Jonny Evans and Patrick McNair are all doubts.
Chelsea (7-1-0) have a major chance to stamp clear authority on their domestic campaign with a victory over United and it would send them potentially eight points clear if West Ham manage to get the best of defending Champions Manchester City on Saturday.
Cesar Azpilicueta is still suspended while Loic Remy, Diego Costa, Andre Schurrle and Ramires are left as game time decisions.
Predicted Score: Manchester United 1-3 Chelsea
Bet 365 Odds: 15/8 Manchester United to win, 13/5 to draw and 6/4 Chelsea to win.
Projected Lineups
Manchester United XI: De Gea: Rafael, Jones, Smalling, Rojo; Herrera, Blind, Fellaini; Maria; Falcao, Persie.
Chelsea XI: Courtois: Ivanovic, Cahill, Terry, Luis; Matic, Fabregas; Willian, Oscar, Hazard: Drogba.