The "Mother of All Bombs" dropped by the US Air Force Thursday in Afghanistan killed 36 Daesh "Islamic State" militants, the Afghan Ministry of Defense said.
The blast destroyed three underground tunnels as well as weapons and ammunition, but no civilians were injured, said a Defense Ministry spokesman.
The largest non-nuclear weapon in the US arsenal was used in conflict for the first time on Thursday.
The 21,000-pound bomb is known as the Massive Ordinance Air Blast bomb, or MOAB. In military circles, the acronym is known better as the "Mother of All Bombs."
Thursday's strike targeted an underground Islamic State complex in a desolate portion of eastern Afghanistan, military officials said.
A local resident living about 1.5 miles from the blast told CNN he heard an "extremely loud boom that smashed the windows of our house."
Former Afghan President Hamid Karzai condemned the attack as "an inhuman and most brutal misuse of our country."
The United States has not confirmed the results of the strike but President Donald Trump called it "another successful job."
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