Chelsea manager Jose Mourinho has a long standing record of having never lost a Premier League fixture at Stamford Bridge.
Saturday Mourinho will host Arsenal manager Arsene Wenger's 1000th match in charge of the Gunners and will be looking to see the Frenchman taste nothing but defeat.
With the Blues having failed to show their best last weekend against Aston Villa there is belief that their midweek exertions could cause them issues with several suspensions also thrown into the mix.
However, Arsenal are likely to have a fight on their hands if they want to get themselves back in the fight for the Premier League title.
Despite Ashley Cole, Ramires and Willian all being absent the Blues will be just as strong as ever with Frank Lampard and Nemanja Matic set to step into the first team.
The Gunners have no fresh injury concerns and are expected to field much the same first team as they did in mid-week.
Blues XI: Cech: Ivanovic, Cahill, Terry, Azpilicueta; Matic, Lampard; Schurrle, Oscar, Hazard; Eto'o.
Gunners XI: Szczesney: Sagna, Mertesacker, Koscielny, Gibbs; Arteta, Flamini; Rosicky, Cazorla, Oxlade-Chamberlain; Giroud.