US national team coach Gregg Berhalter sent Weston McKennie back to Juventus due to COVID-19 protocol breach on Monday.
The US are set to face Honduras in a 2022 World Cup qualifier on Wednesday.
The midielder missed Sunday's 1-1 draw against Canada due to suspension.
He later posted on Instagram that his absence was due to him breaching COVID-19 protocols.
Berhalter said in a statement: "Weston will return to Italy and will be unavailable for the match against Honduras due to a violation of team policy.
"There are high expectations for those who are a part of the U.S. Men's National Team, and in order to be successful it's important that everyone in the group is accountable."
The 23-year-old represented the US national team 25 times and scored 7 goals.
McKennie moved to Juventus in 2020 from Schalke on loan initially before signing a four-year deal in March of 2021.
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