He's known for his close relationship with his legion of adoring fans all over the world.
The One Dance star, currently on his Boy Meets World tour, took to Instagram to slam the rumours, saying he had merely asked the woman to take off her jacket and winter scarf.
He called the allegations 'devastating, saying 'I would never make a disrespectful comment like that in my life towards someone who is wearing one.'
Posting an onstage snap showing him surrounded by adoring fans the Controlla singer said:
'I make a point every night to end my shows on a time of unity and love so, to find out that I am being utilized in a fake media story about me disrespecting Muslims is devastating to me.
'At my show I'm the O2 in London I was talking to 4 women one of whom was wearing a jacket and a winter scarf, I made a comment about taking off the scarf because I enjoy a friendly banter with the fans.
I am well aware of what a hijab is and I would never make a disrespectful comment like that in my life towards someone who is wearing one.'
Rihanna's former beau said he was 'proud that my closest friends and fans come from all different religions and races, and "perhaps whoever made up this story should spend more time learning about other cultures and less time trying to divide us.'
Drake's current tour on behalf of latest album Views will see him travel through England, Germany, the Netherlands, Belgium, Sweden, Denmark, France and Scotland.
It comes amid claims his brief romance with Latina star Jennifer Lopez has fizzled out.
A source told the website: '[They] have taken some time apart, not because they don't want to be with each other, just because their schedules started getting insane.
'J Lo and Drake are still talking, so people should know they are not in any means angry or that some incident happened. It mainly had to do with timing,' the source added.
By Eve Buckland
© Associated Newspapers Ltd.