Russian actress Yulia Peresild and director Klim Shipenko landed as scheduled on Kazakhstan's steppe at 04:36 GMT, according to footage broadcast live by the Russian space agency.
They were ferried back to Terra Firma by cosmonaut Oleg Novitsky, who had been on the space station for the past six months.
'The descent vehicle of the crewed spacecraft Soyuz MS-18 is standing upright and is secure. The crew is feeling good!' Russian space agency Roscosmos tweeted.
Peresild smiled and held a large bouquet of white flowers as journalists clustered around her, though said she felt sad the expedition is over.
'It seemed that 12 days would be a lot, but I did not want to leave when everything was over,' she said.
The filmmakers had blasted off from the Russia-leased Baikonur Cosmodrome in ex-Soviet Kazakhstan earlier this month, traveling to the ISS with veteran cosmonaut Anton Shkaplerov to film scenes for 'The Challenge'.
If the project stays on track, the Russian crew will beat a Hollywood project announced last year by 'Mission Impossible' star Tom Cruise together with NASA and Elon Musk's SpaceX.
The movie's plot, which has been mostly kept under wraps along with its budget, centers around a surgeon who is dispatched to the ISS to save a cosmonaut.
Shkaplerov, 49, along with the two Russian cosmonauts who were already aboard the ISS are said to have cameo roles in the film.
Russian actress Yulia Peresild, 37, is the final crew member to exit the Soyuz spacecraft.— Spaceflight Now (@SpaceflightNow) October 17, 2021
Peresild and crewmate Klim Shipenko flew to the International Space Station to film scenes for a Russian film titled “The Challenge.”https://t.co/lgz8BokYjP pic.twitter.com/mogRt4BnTq
Novitskiy, who transported the two filmmakers back to Earth, is to appear in the movie as the ailing cosmonaut requiring emergency surgery.
The mission was not without small hitches.
As the film crew docked at the ISS earlier this month, Shkaplerov had to switch to manual control.
And when Russian flight controllers on Friday conducted a test on the Soyuz MS-18 spacecraft the ship's thruster fired unexpectedly and destabilized the ISS for 30 minutes, a NASA spokesman told the Russian news agency TASS.
But the spokesman confirmed their departure would go ahead as scheduled.
Their landing, which was documented by a film crew, will also feature in the movie, Konstantin Ernst, the head of the Kremlin-friendly Channel One TV network and a co-producer of 'The Challenge', told AFP.
The mission will add to a long list of firsts for Russia's space industry.
The Soviets launched the first satellite Sputnik and sent into orbit the first animal, a dog named Laika, the first man, Yuri Gagarin, and the first woman, Valentina Tereshkova.
But compared with the Soviet era, modern Russia has struggled to innovate and its space industry is fighting to secure state funding with the Kremlin prioritizing military spending.
Its space agency is still reliant on Soviet-designed technology and has faced a number of setbacks, including corruption scandals and botched launches.
🚀 "Movie crew" is back on Earth again— Russia 🇷🇺 (@Russia) October 17, 2021
Actress Yulia #Peresild & director Klim #Shipenko accompanied by @novitskiy_iss successfully returned home after 12 days shooting in #space aboard of the International @Space_Station!
❤️ Welcome home, guys!
🇷🇺 #RussiansDidIt first indeed! pic.twitter.com/ACfUzjaUz7
Russia is also falling behind in the global space race, facing tough competition from the United States and China, with Beijing showing growing ambitions in the industry.
Russia's Roscosmos was also dealt a blow after SpaceX last year successfully delivered astronauts to the ISS, ending Moscow's monopoly for journeys to the orbital station.
In a bid to spruce up its image and diversify its revenue, Russia's space program revealed this year that it will be reviving its tourism plan to ferry fee-paying adventurers to the ISS.
After a decade-long pause, Russia will send two Japanese tourists - including billionaire Yusaku Maezawa - to the ISS in December, capping a year that has been a milestone for amateur space travel.
© Associated Newspapers Ltd.