Manchester United will be without Wayne Rooney due to suspension for having racked up five yellow cards already this season. Robin Van Persie is believed a possible inclusion for the match, but if the Dutchman cannot go, Javier Hernandez is next in line.
The continued lacking of Michael Carrick is proving to be a bigger loss than many might have thought it do be.
After the Red Devils loss to Everton in midweek, manager David Moyes has to see his team return to winning ways.
However, Newcastle United are looking to also bounce back from a disappointing loss that saw their undefeated November become quickly forgotten by a heart breaking December opener.
Papiss Cisse is still in doubt as to his health and Loic Remy and Shola Ameobi once again are expected to be leading the line.
United have the edge in the pre-match facts as the Red Devils are undefeated in 22 of their last 23 matches against Newcastle in all competitions.
However, Wednesday was the first time Everton have won at Old Trafford since 1992 and Newcastle will hope they can break their duck as well.
United XI: De Gea; Smalling, Vidic, Evans, Evra; Cleverly, Jones; Valencia, Kagawa, Welbeck; Persie.
Newcastle XI: Krul; Debuchy, Williamson, Coloccini, Santon; Sissoko, Cabaye, Tiote, Gouffran; Remy, Ameobi.
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