Napoli will face Wolfsburg and Sevilla will meet Zenit in the quarter-finals of the Europa League.
The Italian side take on Dieter Hecking's men, one of the tournament favourites, for the first time in European competition.
From the beginning of this year's tournament, sides from Russia were not allowed to be drawn aginst sides from Ukraine, for political reasons.
Zenit were drawn first and paired with Sevilla, who are targeting a second consecutive Europa League to add to the back-to-back titles they claimed in 2006 and 2007.
After beating Besiktas in the last-16, Club Brugge, the only unbeaten team in the tournament, will take on Ukrainian side Dnipro, who scraped through on away goals at the expense of Ajax.
Dynamo Kiev, who came from behind in their tie to trounce Everton in the second-leg, face Fiorentina, fresh off of a massive win over Roma in the last round of the competition.
The first legs of the quarter-finals will be played on April 16, with the second legs taking place the following week.
The final will be played at the National Stadium in Warsaw on May 27.
